Involvement of CXCR4 chemokine receptor in metastastic HER2-positive esophageal cancer.

A functional linkage of the structurally unrelated receptors HER2 and CXCR4 has been suggested for breast cancer but has not been evaluated for esophageal carcinoma. The inhibition of HER2 leads to a reduction of primary tumor growth and metastases in an orthotopic model of esophageal carcinoma. The...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Stephanie J Gros, Nina Kurschat, Astrid Drenckhan, Thorsten Dohrmann, Evelyn Forberich, Katharina Effenberger, Uta Reichelt, Robert M Hoffman, Klaus Pantel, Jussuf T Kaifi, Jakob R Izbicki
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	http://europepmc.org/articles/PMC3474831?pdf=render