Identification of CVID Patients With Defects in Immune Repertoire Formation or Specification

Common variable immune deficiency disorder (CVID) is the most clinically relevant cause of antibody failure. It is a highly heterogeneous disease with different underlying etiologies. CVID has been associated with a quantitative B cell defect, however, little is known about the quality of B cells pr...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Pauline A. van Schouwenburg, Hanna IJspeert, Ingrid Pico-Knijnenburg, Virgil A. S. H. Dalm, P. Martin van Hagen, David van Zessen, Andrew P. Stubbs, Smita Y. Patel, Mirjam van der Burg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Subjects:	common variable immune deficiency disorder B-cell receptor repertoire repertoire formation repertoire specification germinal center somatic hypermutation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02545/full