All-Trans Retinoic Acid Induces Differentiation and Downregulates Stemness Markers and MGMT Expression in Glioblastoma Stem Cells
Background: Glioblastoma (GBM) remains almost uniformly fatal, owing in part to therapy-resistant cancer stem-like cells (CSCs) and to temozolomide (TMZ) resistance driven by O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT). Differentiation therapy with all-trans retinoic acid (A...
| Published in: | Cells |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/14/10/746 |