Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

Abstract Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification. However, their applications have bee...

Full description

Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Xiaowei Zhu, Suling Ding, Hui Li, Zhiwei Zhang, Lili Xu, Jian Wu, Xiangfei Wang, Yunzeng Zou, Xiangdong Yang, Junbo Ge
Format:	Article
Language:	English
Published:	BMC 2020-03-01
Subjects:	Human induced pluripotent stem cells Cardiac differentiation Histamine Histamine receptor
Online Access:	http://link.springer.com/article/10.1186/s13287-020-1551-z