Mutations close to a hub residue affect the distant active site of a GH1 β-glucosidase.

The tertiary structure of proteins has been represented as a network, in which residues are nodes and their contacts are edges. Protein structure networks contain residues, called hubs or central, which are essential to form short connection pathways between any pair of nodes. Hence hub residues may...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Valquiria P Souza, Cecília M Ikegami, Guilherme M Arantes, Sandro R Marana
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198696/1/pone.0198696.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T105503Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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