Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE−/− mice

Pyroptosis is a form of pro-inflammatory cell death that can be mediated by gasdermin D (GSDMD) activation induced by inflammatory caspases such as caspase-1. Emerging evidence suggests that targeting GSDMD activation or pyroptosis may facilitate the reduction of vascular inflammation and atheroscle...

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Published in:	Frontiers in Pharmacology
Main Authors:	Bao-Li Zhang, Peng Yu, En-Yong Su, Chun-Yu Zhang, Shi-Yao Xie, Xue Yang, Yun-Zeng Zou, Ming Liu, Hong Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	atherosclerosis GSDMD macrophage pyroptosis vascular inflammation Z-LLSD-FMK
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1184588/full