New Insights into the Opioid Analgesic Profile of <i>cis</i>-(−)-<i>N</i>-Normetazocine-derived Ligands

In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the <i>N</i>-substituent of our lead compound LP1 was repla...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	μ opioid receptor competition binding assay mouse vas deferens assay tail-flick test CFA test
Online Access:	https://www.mdpi.com/1420-3049/28/12/4827