Polygenic prediction of human longevity on the supposition of pervasive pleiotropy

Abstract The highly polygenic nature of human longevity renders pleiotropy an indispensable feature of its genetic architecture. Leveraging the genetic correlation between aging-related traits (ARTs), we aimed to model the additive variance in lifespan as a function of the cumulative liability from...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-08-01
Subjects:	Pleiotropy Polygenic score Common variants Aging Lifespan Longevity
Online Access:	https://doi.org/10.1038/s41598-024-69069-0