In Vitro and In Vivo Antitumor Activity of Indolo[2,3-<i>b</i>] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target co...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Najla Altwaijry, Samah El-Ghlban, Ibrahim E.-T. El Sayed, Mohamed El-Bahnsawye, Asmaa I. Bayomi, Rehab M. Samaka, Elkhabiry Shaban, Elshaymaa I. Elmongy, Thanaa A. El-Masry, Hytham M. A. Ahmed, Nashwah G. M. Attallah
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Subjects:	indoloquinoline cancer cell cycle apoptosis antioxidant enzymes
Online Access:	https://www.mdpi.com/1420-3049/26/3/754