Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD)...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Jean Claude Alvarez, Benjamin Davido, Pierre Moine, Isabelle Etting, Djillali Annane, Islam Amine Larabi, Nicolas Simon
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Subjects:	hydroxychloroquine desethylhydroxychloroquine desethylchloroquine didesethylchloroquine PK/PD COVID-19
Online Access:	https://www.mdpi.com/1424-8247/15/2/256