Nasal immunization with Streptococcus mutans membrane vesicles and eggshell-derived hydroxyapatites elicits enhanced antigen-specific mucosal IgA responses

Abstract Nasal vaccines characterized by secretory IgA (SIgA) induction are effective in preventing mucosal infection. SIgA induction is potentiated by mucosal adjuvants, and the exploration of new safe and effective candidates is important. Nanosized hydroxyapatites (HAs) have the potential to enha...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Tomomi Hashizume-Takizawa, Chihiro Mochizuki, Yuki Sakai, Koichi Nakamura, Hirotaka Kobayashi, Hidenobu Senpuku
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Subjects:	Nasal immunization Mucosal adjuvant Eggshell Hydroxyapatites Membrane vesicle Glucosyltransferases
Online Access:	https://doi.org/10.1038/s41598-025-19334-7