5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action

In the effort to identify and develop new HIV-1 inhibitors endowed with innovative mechanisms, we focused our attention on the possibility to target more than one viral encoded enzymatic function with a single molecule. In this respect, we have previously identified by virtual screening a new indoli...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Angela Corona, Rita Meleddu, Olivier Delelis, Frederic Subra, Filippo Cottiglia, Francesca Esposito, Simona Distinto, Elias Maccioni, Enzo Tramontano
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	antiviral agents drug design multitarget inhibitors RT inhibitors IN inhibitors
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1193280/full