Alcohol use disorder disrupts BDNF maturation via the PAI-1 pathway which could be reversible with abstinence

Abstract The plasminogen activator inhibitor-1 (PAI-1)→mature brain-derived neurotrophic factor (mBDNF) pathway plays a pivotal role in the conversion of probrain-BDNF (ProBDNF) to mBDNF, but its clinical relevance in patients with alcohol use disorder (AUD) remains unknown. Enzyme-linked immunosorb...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Shouqing Liu, Xin’e Xie, Dandan Zhao, Nini Jin, Yongwei Hu, Weiping Wang, Xiaodong Luo, Gang Li, Zhirong Yang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Subjects:	Alcohol use disorder (AUD) Mature brain-derived neurotrophic factor (mBDNF) Pro-brain-derived neurotrophic factor (ProBDNF) Tissue plasminogen activator (tPA) Plasminogen activator inhibitor-1 (PAI-1) Abstinence treatment
Online Access:	https://doi.org/10.1038/s41598-024-73347-2