The unique hypertrophic and fibrotic features of neonatal right ventricle in response to pressure overload

Abstract Pediatric heart failure (HF) research remains in its infancy partly due to the lack of neonatal rat/mouse models of HF. The aim of the study is to introduce a neonatal rat/mouse model of right ventricular (RV) pressure overload (RVPO), a significant cause of pediatric HF, and to uncover the...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yingying Xiao, Yiting Xue, Debao Li, Lincai Ye, Zheng Wang, Sixie Zheng, Peisen Ruan, Hao Chen, Haifa Hong
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Pressure overload Right heart failure Pediatric Single-cell sequencing Right ventricle
Online Access:	https://doi.org/10.1038/s41598-025-01427-y