The unique hypertrophic and fibrotic features of neonatal right ventricle in response to pressure overload

Abstract Pediatric heart failure (HF) research remains in its infancy partly due to the lack of neonatal rat/mouse models of HF. The aim of the study is to introduce a neonatal rat/mouse model of right ventricular (RV) pressure overload (RVPO), a significant cause of pediatric HF, and to uncover the...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Yingying Xiao, Yiting Xue, Debao Li, Lincai Ye, Zheng Wang, Sixie Zheng, Peisen Ruan, Hao Chen, Haifa Hong
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Pressure overload Right heart failure Pediatric Single-cell sequencing Right ventricle
Online Access:	https://doi.org/10.1038/s41598-025-01427-y

Similar Items

Postnatal Right Ventricular Developmental Track Changed by Volume Overload
by: Sijuan Sun, et al.
Published: (2021-08-01)

Human Neonatal Thymus Mesenchymal Stem/Stromal Cells and Chronic Right Ventricle Pressure Overload
by: Josue Chery, et al.
Published: (2019-02-01)

Ability of the Right Ventricle to Serve as a Systemic Ventricle in Response to the Volume Overload at the Neonatal Stage
by: Chunxia Zhou, et al.
Published: (2022-12-01)

The impact of phosphodiesterase‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload
by: Tereza Tykvartova, et al.
Published: (2024-02-01)

Discrepancy of clinical, laboratory and instrumental picture in patients with pulmonary embolism
by: A. G. Pronin, et al.
Published: (2022-05-01)

A case of isolated right ventricle noncompaction with ST-Elevation chest leads
by: Sourabh Aggarwal, et al.
Published: (2016-01-01)

IMPACT OF THE RIGHT VENTRICLE DYSFUNCTION ON CHRONIC HEART FAILURE PRESENTATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
by: N. G. Poteshkina, et al.
Published: (2016-08-01)

Volume overload impedes the maturation of sarcomeres and T-tubules in the right atria: a potential cause of atrial arrhythmia following delayed atrial septal defect closure
by: Zhuoya Dong, et al.
Published: (2023-10-01)

It's All About That Right Ventricle
by: Ambreen F. Ali, et al.
Published: (2024-04-01)

A rare unclassified cardiomyopathy: isolated right ventricle noncompaction
by: Göksel Açar, et al.
Published: (2013-05-01)

Perioperative management of the vulnerable and failing right ventricle
by: R. C. Arora, et al.
Published: (2024-05-01)

Right ventricular volume overload reboots cardiomyocyte proliferation via immune responses
by: Chunxia Zhou, et al.
Published: (2024-11-01)

Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle
by: Argen Mamazhakypov, et al.
Published: (2024-02-01)

Right Ventricle and Radiotherapy: More Questions than Answers
by: Marijana Tadic, et al.
Published: (2023-01-01)

The systemic right ventricle: Is the tricuspid valve its “Achilles” heel’?
by: Ashish H. Shah, et al.
Published: (2025-03-01)

Penetrating Pellet Gun Injury to the Neck and Embolization to the Right Ventricle
by: Victoria Fanucci, BS, et al.
Published: (2025-07-01)

Unusual involvement of right ventricle in patient with Rosai–Dorfman disease
by: Belma Yaman, et al.
Published: (2019-11-01)

Borderline Ventricles: From Evaluation to Treatment
by: Giuseppe Antonio Mazza, et al.
Published: (2024-04-01)

A simple goiter of the right ventricle: case report and literature review
by: Shuai Luo, et al.
Published: (2024-11-01)

Takotsubo cardiomyopathy and new-onset right bundle branch block in uncomplicated right ventricle pacing: Cause or coincidence?
by: Manjappa Mahadevappa, et al.
Published: (2021-01-01)

Revisiting Folger's pouch in double-chambered right ventricle
by: Sakshi Sachdeva, et al.
Published: (2022-01-01)

Right ventricle/interventricular septum electrophysiological anatomy (determination of optimal right ventricular lead placement)
by: М. В. Диденко, et al.
Published: (2015-10-01)

Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study
by: Nadine Al‐Naamani, et al.
Published: (2016-12-01)

Predictive criteria for the function of the right ventricle of the heart during mechanical bypass of the left ventricle
by: D. D. Uzunin, et al.
Published: (2021-12-01)

DIASTOLIC DYSFUNCTION OF THE RIGHT VENTRICLE IN CORONARY HEART DISEASE PATIENTS
by: O. G. Arkhipov, et al.
Published: (2017-03-01)

Prevalence of Right Ventricle Strain Changes following Anthracycline Therapy
by: Michal Laufer-Perl, et al.
Published: (2022-02-01)

Three-Dimensional Reconstruction of the Right Ventricle from a Radial Basis Morphing of the Inner Surface
by: Carlotta Fontana, et al.
Published: (2024-10-01)

Keep the Right in Mind—A Focused Approach to Right Ventricle-Predominant Cardiogenic Shock
by: Viana Jacquline Copeland, et al.
Published: (2023-01-01)

Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling
by: Xavier Alexander Lee, et al.
Published: (2025-09-01)

THE PROCESS OF COMBINED INFERIOR MYOCARDIAL INFARCTION AND RIGHT VENTRICLE MYOCARDIAL INFARCTION WITH TRANSIENT ARTERIAL HYPOTENSION
by: Z. M. Chazymova, et al.
Published: (2017-12-01)

Hemodynamic Melody of Postnatal Cardiac and Pulmonary Development in Children with Congenital Heart Diseases
by: Sixie Zheng, et al.
Published: (2024-03-01)

AVEIR leadless pacemaker implantation in a patient with a small right ventricle
by: Ayan S. Abdrakhmanov, et al.
Published: (2025-10-01)

EVALUATION OF RIGHT VENTRICLE SYSTOLIC AND DIASTOLIC FUNCTION IN PATIENTS WITH PAROXYSMAL ATRIAL FIBRILLATION
by: Bilal Cuglan, et al.
Published: (2020-08-01)

Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle
by: Valérie Spalart, et al.
Published: (2024-09-01)

Double-chambered right ventricle in a 16-year-old patient with Williams syndrome
by: Wojciech Mądry, et al.
Published: (2017-12-01)

Isolated metastasis of hepatocellular carcinoma in the right ventricle
by: Xin-tong Zhang, et al.
Published: (2019-12-01)

Unlocking the Potential: Angiotensin Receptor Neprilysin and Sodium Glucose Co-Transporter 2 Inhibitors for Right Ventricle Dysfunction in Heart Failure
by: Bibhuti B. Das
Published: (2024-07-01)

Surgical Experiences and Results of the Management of Double Chambered Right Ventricle
by: Mujahid Razzaq, et al.
Published: (2024-06-01)

The Role of Magnetic Resonance Imaging in Diagnosis of Arrhythmogenic Rıght Ventricle Dysplasia
by: Hadi SASANİ, et al.
Published: (2019-08-01)

ROLE OF ECHOCARDIOSCOPY IN ASSESSMENT OF STRUCTURAL-FUNCTIONAL PECULIARITIES OF A RIGHT VENTRICLE OF HEART IN CHILDREN WITH CARDIOGENIC SYNCOPE
by: V. A. Litkin, et al.
Published: (2012-11-01)