Tumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming

Abstract Background Extracellular ATP–AMP–adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the conversion of ATP to AMP is primarily catalysed by Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1/CD39), a widely studied ATPase, w...

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Published in:	Cell Communication and Signaling
Main Authors:	Mengchen Shi, Linsen Ye, Lu Zhao, Lingyuan He, Junxiong Chen, Jingdan Zhang, Yixi Su, Haiyan Dong, Jiaqi Liu, Liumei Liang, Wenwen Zheng, Yanhong Xiao, Huanliang Liu, Xiangling Yang, Zihuan Yang
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Colon cancer Exosome Adenosine Ectonucleoside triphosphate diphosphohydrolase CD8+ T cell
Online Access:	https://doi.org/10.1186/s12964-024-01654-2