Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway

IntroductionCerebral ischemia–reperfusion (IR) causes severe secondary brain injury. Previous studies have demonstrated that ferroptosis is involved in IR-induced brain injury. However, whether IR induces ferroptosis in brain microvascular endothelial cells (BMVECs) is not fully understood.Materials...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	ferroptosis ischemia/reperfusion brain microvascular endothelial cells SESN2 system Xc- RNA-seq
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2024.1504114/full