Engineering and characterization of Hu3A4: A novel humanized antibody with potential as a therapeutic agent against myeloid lineage leukemias

Leukemia stem cells (LSCs) play a critical role in the initiation, recurrence, and resistance to treatment of leukemia. Eradicating LSCs is crucial for the complete elimination of the disease. CD45RA is identified as an important marker for LSC subsets in acute myeloid leukemia (AML), providing a st...

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Bibliographic Details

Published in:	Neoplasia: An International Journal for Oncology Research
Main Authors:	Sisi Li, Zhujun Wang, Xiaoping Guo, Yongmin Tang
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	CD45RA Humanized antibody CDR grafting antibody Leukemic stem cells 3A4 Targeting therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558624001258