Impact of Oncogenic Changes in p53 and KRAS on Macropinocytosis and Ferroptosis in Colon Cancer Cells and Anticancer Efficacy of Niclosamide with Differential Effects on These Two Processes

Mutations in p53 and KRAS are seen in most cases of colon cancer. The impact of these mutations on signaling pathways related to cancer growth has been studied in depth, but relatively less is known on their effects on amino acid transporters in cancer cells. This represents a significant knowledge...

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Bibliographic Details

Published in:	Cells
Main Authors:	Nhi T. Nguyen, Souad R. Sennoune, Gunadharini Dharmalingam-Nandagopal, Sathish Sivaprakasam, Yangzom D. Bhutia, Vadivel Ganapathy
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	p53 deletion KRAS mutation SLC7A11 SLC38A5 ferroptosis macropinocytosis
Online Access:	https://www.mdpi.com/2073-4409/13/11/951