The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

Ras association domain family protein 1A (RASSF1A) is a tumor suppressor gene silenced in cancer. Here we report that RASSF1A is a novel regulator of intestinal inflammation as Rassf1a(+/-) , Rassf1a(-/-) and an intestinal epithelial cell specific knockout mouse (Rassf1a (IEC-KO) ) rapidly became si...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Marilyn Gordon, Mohamed El-Kalla, Yuewen Zhao, Yahya Fiteih, Jennifer Law, Natalia Volodko, Anwar Anwar-Mohamed, Ayman O S El-Kadi, Lei Liu, Jeff Odenbach, Aducio Thiesen, Christina Onyskiw, Haya Abu Ghazaleh, Jikyoung Park, Sean Bong Lee, Victor C Yu, Carlos Fernandez-Patron, R Todd Alexander, Eytan Wine, Shairaz Baksh
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	https://doi.org/10.1371/journal.pone.0075483