Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease

Abstract Background The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but the associated molecular mechanisms, particularly with respect to the high-risk APOE4/4 genotype, are not well understood. For this purpose, we developed a multicellular isogenic...

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Bibliographic Details

Published in:	Fluids and Barriers of the CNS
Main Authors:	Undine Haferkamp, Carla Hartmann, Chaudhry Luqman Abid, Andreas Brachner, Alevtina Höchner, Anna Gerhartl, Bernadette Harwardt, Selin Leckzik, Jennifer Leu, Marco Metzger, Marina Nastainczyk-Wulf, Winfried Neuhaus, Sabrina Oerter, Ole Pless, Dan Rujescu, Matthias Jung, Antje Appelt-Menzel
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Apolipoprotein E Human induced pluripotent cells Blood-brain barrier Neurovascular unit Alzheimer disease Late-onset Alzheimer disease
Online Access:	https://doi.org/10.1186/s12987-023-00471-y