Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer

Abstract Background Studies have shown that oxidative stress and its resistance plays important roles in the process of tumor metastasis, and mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage is an important molecular event in oxidative stress. In lung cancer, the normal fibroblas...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Zhuan Zhou, Chunhui Qu, Peijun Zhou, Qin Zhou, Dan Li, Xia Wu, Lifang Yang
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Extracellular vesicles Cancer-associated fibroblasts Mitophagy mtDNA Lung cancer Metastasis
Online Access:	https://doi.org/10.1186/s13046-024-03077-w