SENP5 promotes homologous recombination-mediated DNA damage repair in colorectal cancer cells through H2AZ deSUMOylation

Abstract Background Neoadjuvant radiotherapy has been used as the standard treatment of colorectal cancer (CRC). However, radiotherapy resistance often results in treatment failure. To identify radioresistant genes will provide novel targets for combined treatments and prognostic markers. Methods Th...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Tingting Liu, Hang Wang, Yuanyuan Chen, Zhijie Wan, Zhipeng Du, Hui Shen, Yue Yu, Shengzhe Ma, Ying Xu, Zhuqing Li, Nanxi Yu, Fangxiao Zhang, Kun Cao, Jianming Cai, Wei Zhang, Fu Gao, Yanyong Yang
Format:	Article
Language:	English
Published:	BMC 2023-09-01
Subjects:	Cancer resistance SENP5 deSUMOylation DNA damage repair
Online Access:	https://doi.org/10.1186/s13046-023-02789-9