Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation

Nsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9.

Bibliographic Details
Published in:Communications Biology
Main Authors: Lin Yang, Zhenxing Ren, Shenyu Yan, Ling Zhao, Jie Liu, Lijun Zhao, Zhen Li, Shanyu Ye, Aijun Liu, Xichan Li, Jiasong Guo, Wei Zhao, Weihong Kuang, Helu Liu, Dongfeng Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Online Access:https://doi.org/10.1038/s42003-022-03420-x

Internet

https://doi.org/10.1038/s42003-022-03420-x

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