Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation
Nsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9.
| Published in: | Communications Biology |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Online Access: | https://doi.org/10.1038/s42003-022-03420-x |
| _version_ | 1851900572136898560 |
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| author | Lin Yang Zhenxing Ren Shenyu Yan Ling Zhao Jie Liu Lijun Zhao Zhen Li Shanyu Ye Aijun Liu Xichan Li Jiasong Guo Wei Zhao Weihong Kuang Helu Liu Dongfeng Chen |
| author_facet | Lin Yang Zhenxing Ren Shenyu Yan Ling Zhao Jie Liu Lijun Zhao Zhen Li Shanyu Ye Aijun Liu Xichan Li Jiasong Guo Wei Zhao Weihong Kuang Helu Liu Dongfeng Chen |
| author_sort | Lin Yang |
| collection | DOAJ |
| container_title | Communications Biology |
| description | Nsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9. |
| format | Article |
| id | doaj-art-e7b6748cf33e40f78197df64d04c43fb |
| institution | Directory of Open Access Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-e7b6748cf33e40f78197df64d04c43fb2025-08-19T22:06:06ZengNature PortfolioCommunications Biology2399-36422022-05-015111310.1038/s42003-022-03420-xNsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiationLin Yang0Zhenxing Ren1Shenyu Yan2Ling Zhao3Jie Liu4Lijun Zhao5Zhen Li6Shanyu Ye7Aijun Liu8Xichan Li9Jiasong Guo10Wei Zhao11Weihong Kuang12Helu Liu13Dongfeng Chen14Shenzhen Hospital of Integrated Traditional Chinese and Western MedicineShanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong KongAcademy of Integrative Medicine, Shanghai University of Traditional Chinese MedicineShenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen Hospital of Integrated Traditional Chinese and Western MedicineShenzhen Hospital of Integrated Traditional Chinese and Western MedicineDepartment of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese MedicineDepartment of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese MedicineSchool of Chinese Herbal Medicine, Guangzhou University of Chinese MedicineDepartment of Histology and Embryology, Southern Medical UniversityRNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Sun Yat-sen UniversityGuangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical UniversityShenzhen Hospital of Integrated Traditional Chinese and Western MedicineDepartment of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese MedicineNsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9.https://doi.org/10.1038/s42003-022-03420-x |
| spellingShingle | Lin Yang Zhenxing Ren Shenyu Yan Ling Zhao Jie Liu Lijun Zhao Zhen Li Shanyu Ye Aijun Liu Xichan Li Jiasong Guo Wei Zhao Weihong Kuang Helu Liu Dongfeng Chen Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title | Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title_full | Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title_fullStr | Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title_full_unstemmed | Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title_short | Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation |
| title_sort | nsun4 and mettl3 mediated translational reprogramming of sox9 promotes bmsc chondrogenic differentiation |
| url | https://doi.org/10.1038/s42003-022-03420-x |
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