Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease

Abstract Background Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer’s disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit imaging markers in preclinical FAD. M...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Familial Alzheimer’s disease Gene mutation Neuropsychology Diffusion tensor imaging Resting state functional MRI
Online Access:	https://doi.org/10.1186/s13195-023-01192-y