Targeting RNA splicing modulation: new perspectives for anticancer strategy?

Abstract The excision of introns from pre-mRNA is a crucial process in the expression of the majority of genes. Alternative splicing allows a single gene to generate diverse mRNA and protein products. Aberrant RNA splicing is recognized as a molecular characteristic present in almost all types of tu...

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الحاوية / القاعدة:	Journal of Experimental & Clinical Cancer Research
المؤلفون الرئيسيون:	Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2025-01-01
الموضوعات:	Cancer Alternative splicing Splicing modulators Splice-switching ASO Targeted therapy
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13046-025-03279-w