Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer

Abstract Understanding the cellular origins and early evolutionary dynamics that drive the initiation of carcinogenesis is critical to advancing early detection and prevention strategies. By characterizing key molecular, cellular and niche events at the precancerous tipping point of early gastric ca...

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Bibliographic Details

Published in:	Signal Transduction and Targeted Therapy
Main Authors:	Pingting Gao, Chunman Zuo, Wei Yuan, Jiabin Cai, Xiaoqiang Chai, Ruijie Gong, Jia Yu, Lu Yao, Wei Su, Zuqiang Liu, Shengli Lin, Yun Wang, Mingyan Cai, Lili Ma, Quanlin Li, Pinghong Zhou
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-09-01
Online Access:	https://doi.org/10.1038/s41392-025-02390-w