Tromethamine improves mucociliary clearance in cystic fibrosis pigs

Abstract In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl− and HCO3− secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mechanisms: Rapid ASL bacterial killing and mucociliary tr...

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Bibliographic Details
Published in:Physiological Reports
Main Authors: Jamison J. Ash, Brieanna M. Hilkin, Nicholas D. Gansemer, Eric A. Hoffman, Joseph Zabner, David A. Stoltz, Mahmoud H. Abou Alaiwa
Format: Article
Language:English
Published: Wiley 2022-09-01
Subjects:
CT imaging
cystic fibrosis
mucociliary transport
therapeutics
Online Access:https://doi.org/10.14814/phy2.15340

Internet

https://doi.org/10.14814/phy2.15340

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