Tromethamine improves mucociliary clearance in cystic fibrosis pigs

Abstract In cystic fibrosis (CF), the loss of cystic fibrosis transmembrane conductance regulator (CFTR) mediated Cl− and HCO3− secretion across the epithelium acidifies the airway surface liquid (ASL). Acidic ASL alters two key host defense mechanisms: Rapid ASL bacterial killing and mucociliary tr...

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出版年:	Physiological Reports
主要な著者:	Jamison J. Ash, Brieanna M. Hilkin, Nicholas D. Gansemer, Eric A. Hoffman, Joseph Zabner, David A. Stoltz, Mahmoud H. Abou Alaiwa
フォーマット:	論文
言語:	英語
出版事項:	Wiley 2022-09-01
主題:	CT imaging cystic fibrosis mucociliary transport therapeutics
オンライン･アクセス:	https://doi.org/10.14814/phy2.15340