CXCR1 and CXCR2 are potential neutrophil extracellular trap-related treatment targets in ulcerative colitis: insights from Mendelian randomization, colocalization and transcriptomic analysis

ObjectivesThere is already substantial evidence indicating that neutrophil extracellular trap (NET) formation contributes to the inflammatory cascade in ulcerative colitis (UC). However, the precise regulatory mechanisms governing this process remain elusive. This study aimed to determine the role o...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yichuan Xv, Yiyi Feng, Jiang Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	Mendelian randomization neutrophil extracellular trap causal effect ulcerative colitis innate immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1425363/full