Immune evasion in cell-based immunotherapy: unraveling challenges and novel strategies

Abstract Cell-based immunotherapies (CBIs), notably exemplified by chimeric antigen receptor (CAR)-engineered T (CAR-T) cell therapy, have emerged as groundbreaking approaches for cancer therapy. Nevertheless, akin to various other therapeutic modalities, tumor cells employ counterstrategies to mani...

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Bibliographic Details

Published in:	Journal of Biomedical Science
Main Authors:	Yan-Ruide Li, Tyler Halladay, Lili Yang
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Immune evasion Cell-based immunotherapies (CBIs) Chimeric antigen receptor (CAR) CAR-engineered T (CAR-T) cell therapy Tumor microenvironment (TME) Immune checkpoint proteins
Online Access:	https://doi.org/10.1186/s12929-024-00998-8