Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center

Abstract Background Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides having the characteristic zinc coordination...

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Bibliographic Details

Published in:	BMC Molecular and Cell Biology
Main Authors:	Carina Jägers, Henk Roelink
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Subjects:	Shh signaling Zinc metallopeptidases Extracellular matrix BacHh
Online Access:	https://doi.org/10.1186/s12860-021-00359-5