Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

The isolation of haploid cell lines has recently allowed the power of forward genetic screens to be applied to mammalian cells. The interest in applying this powerful genetic approach to a mammalian system is only tempered by the limited utility of these screens, if confined to lethal phenotypes. He...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Lidia M Duncan, Richard T Timms, Eszter Zavodszky, Florencia Cano, Gordon Dougan, Felix Randow, Paul J Lehner
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039651&type=printable