p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation

Introduction: Escape from immunosurveillance is a hallmark of chronic lymphocytic leukemia (CLL) cells. In the protective niche of lymphoid organs, leukemic cells suppress the ability of T lymphocytes to form the immune synapse (IS), thereby hampering T-cell mediated anti-tumoral activities. By bind...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Ludovica Lopresti, Nagaja Capitani, Vanessa Tatangelo, Carmela Tangredi, Gioia Boncompagni, Federica Frezzato, Andrea Visentin, Giuseppe Marotta, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Livio Trentin, Cosima T. Baldari, Laura Patrussi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	PD-L1 immune checkpoint CLL p66Shc immune synapse ROS
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1297116/full