Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer

Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours. While many cancers display an ongoing CIN phenotype, cells can also be aneuploid without displaying CIN. CIN drives...

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Bibliographic Details

Published in:	Open Biology
Main Authors:	Lin Zhou, Laura J. Jilderda, Floris Foijer
Format:	Article
Language:	English
Published:	The Royal Society 2020-09-01
Subjects:	chromosomal instability aneuploidy cancer aneuploidy tolerance intervention
Online Access:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200148