Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound

ABSTRACT The implementation of prospective drug resistance (DR) studies in the research-and-development (R&D) pipeline is a common practice for many infectious diseases but not for neglected tropical diseases (NTDs). Here, we explored and demonstrated the importance of this approach using as par...

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Bibliographic Details

Published in:	mBio
Main Authors:	Aya Hefnawy, Gabriel Negreira, Marlene Jara, James A. Cotton, Ilse Maes, Erika D’Haenens, Hideo Imamura, Bart Cuypers, Pieter Monsieurs, Christina Mouchtoglou, Hans De Winter, Isabel Pintelon, Jean-Pierre Timmermans, Matt Berriman, Mandy Sanders, Julio Martin, Geraldine de Muylder, Jean-Claude Dujardin, Yann G.-J. Sterckx, Malgorzata Anna Domagalska
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-02-01
Subjects:	CRISPR-Cas9 Leishmania drug resistance mechanisms dynamin genomics
Online Access:	https://journals.asm.org/doi/10.1128/mbio.03264-21