MND1 enables homologous recombination in somatic cells primarily outside the context of replication

Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co‐factor MND1 facilitates the repair of DSBs in somatic cells. We show that MND1 localizes to DSBs, where it stimulates DNA repa...

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Bibliographic Details

Published in:	Molecular Oncology
Main Authors:	Lisa Koob, Anoek Friskes, Louise vanBergen, Femke M. Feringa, Bram van denBroek, Emma S. Koeleman, Ellis vanBeek, Michael Schubert, Vincent A. Blomen, Thijn R. Brummelkamp, Lenno Krenning, René H. Medema
Format:	Article
Language:	English
Published:	Wiley 2023-07-01
Subjects:	DNA damage response double‐strand breaks homologous recombination irradiation
Online Access:	https://doi.org/10.1002/1878-0261.13448