Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes

<p>Abstract</p> <p>Background</p> <p>The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol in insulin target tissues. In people with type 2 diabetes, skeletal muscle (SkM) 11βHSD1 is upregulated by the potent gluco...

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Bibliographic Details

Published in:	Clinical Epigenetics
Main Authors:	Inder Warrick J, Obeyesekere Varuni R, Jang Christina, Saffery Richard
Format:	Article
Language:	English
Published:	BMC 2012-12-01
Subjects:	11β-Hydroxysteroid dehydrogenase-1 Cortisol Diabetes Epigenetics DNA methylation
Online Access:	http://www.clinicalepigeneticsjournal.com/content/4/1/24