Insights into the action of the pharmaceutical metformin: Targeted inhibition of the gut microbial enzyme agmatinase

Summary: Metformin is the first-line treatment for type 2 diabetes, yet its mechanism of action is not fully understood. Recent studies suggest metformin’s interactions with gut microbiota are responsible for exerting therapeutic effects. In this study, we report that metformin targets the gut micro...

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Bibliographic Details

Published in:	iScience
Main Authors:	Lambros J. Tassoulas, Lawrence P. Wackett
Format:	Article
Language:	English
Published:	Elsevier 2024-02-01
Subjects:	Pharmaceutical science Geomicrobiology Microbiology Microbiome
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004224001214