Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations

Abstract Well‐preserved molecular cargo in circulating extracellular vesicles (EVs) offers an ideal material for detecting oncogenic gene alterations in cancer patients, providing a noninvasive diagnostic solution for detection of disease status and monitoring treatment response. Therefore, technolo...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Na Sun, Benjamin V. Tran, Zishan Peng, Jing Wang, Ceng Zhang, Peng Yang, Tiffany X. Zhang, Josephine Widjaja, Ryan Y. Zhang, Wenxi Xia, Alexandra Keir, Jia‐Wei She, Hsiao‐hua Yu, Jing‐Jong Shyue, Hongguang Zhu, Vatche G. Agopian, Renjun Pei, James S. Tomlinson, Jeffrey A Toretsky, Steven J. Jonas, Noah Federman, Shaohua Lu, Hsian‐Rong Tseng, Yazhen Zhu
Format:	Article
Language:	English
Published:	Wiley 2022-05-01
Subjects:	click chemistry extracellular vesicles gene alteration quantification lipid labeling
Online Access:	https://doi.org/10.1002/advs.202105853