HIV subtype-specific gp140-CD4 binding, Temsavir efficacy, and identification of novel adhesion inhibitors against Chinese HIV strains

IntroductionThe HIV epidemic in China is characterized by significant genetic diversity with multiple circulating recombinant forms (CRFs). The gp120-CD4 interaction, essential for viral cellular entry, exhibits subtype-dependent structural variations that compromise therapeutic efficacy. Although t...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Tianyang Liu, Xiaowen Li, Xiaolin Yang, Shengjie Zhang, Yao Wang, Siwei Zhang, Lin Cheng, Shanshan Tang, Fuxiang Wang, Yao Zhao, Hongzhou Lu, Lanlan Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	HIV-1 gp140-CD4 binding Temsavir CRF subtypes adhesion inhibitors
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1648546/full