Myocarditis Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-Antigen Presentation by Conventional Type 2 Dendritic Cells

Autoimmune myocarditis often leads to dilated cardiomyopathy (DCM). Although T cell reactivity to cardiac self-antigen is common in the disease, it is unknown which antigen presenting cell (APC) triggers autoimmunity. Experimental autoimmune myocarditis (EAM) was induced by immunizing mice with α-my...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Katrien Van der Borght, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Gert Van Isterdael, Veronika Nindl, Yvan Saeys, Louis Boon, Burkhard Ludewig, Thierry C. Gillebert, Bart N. Lambrecht
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Subjects:	dendritic cells myocarditis autoimmunity heart failure autoreactive T cells
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02714/full