PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression

Abstract Only a minority of cancer patients benefit from immune checkpoint blockade therapy. Sophisticated cross-talk among different immune checkpoint pathways as well as interaction pattern of immune checkpoint molecules carried on circulating small extracellular vesicles (sEV) might contribute to...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lin-Zhou Zhang, Jie-Gang Yang, Gai-Li Chen, Qi-Hui Xie, Qiu-Yun Fu, Hou-Fu Xia, Yi-Cun Li, Jue Huang, Ye Li, Min Wu, Hai-Ming Liu, Fu-Bing Wang, Ke-Zhen Yi, Huan-Gang Jiang, Fu-Xiang Zhou, Wei Wang, Zi-Li Yu, Wei Zhang, Ya-Hua Zhong, Zhuan Bian, Hong-Yu Yang, Bing Liu, Gang Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Online Access:	https://doi.org/10.1038/s41467-024-48200-9