Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity

Background: Alzheimer’s disease (AD) involves impairment of Aβ clearance. Neprilysin (NEP) is the most efficient Aβ peptidase. Enhancement of the activity or expression of NEP may provide a prominent therapeutic strategy against AD. Aims: Ten hydroxylated monocarbonyl curcumin derivatives were desig...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Dimitris Matiadis, See-Ting Ng, Eric H.-L. Chen, Georgia Nigianni, Veroniki P. Vidali, Aleksander Canko, Rita P.-Y. Chen, Marina Sagnou
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	monocarbonyl curcumin derivatives neprilysin amyloid cleavage Aβ amyloid peptide Alzheimer’s disease
Online Access:	https://www.mdpi.com/2227-9059/9/8/955