Role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in the anesthetized atrioventricular block rabbit

We analyzed role of cardiac α1-adrenoreceptors for the torsadogenic action of IKr blocker nifekalant in isoflurane-anesthetized atrioventricular block rabbits. Bradycardia was induced by atrioventricular node ablation, and the ventricle was electrically driven at a constant rate of 60 beats/min thro...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Satoshi Kawakami, Ryuichi Kambayashi, Kazuhiro Takada, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Subjects:	Methoxamine α1 adrenoreceptor Torsade de pointes QT-Interval prolongation Rabbit heart
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861322000536