Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study

Abstract Background Synaptic homeostasis, maintained by microglia and astroglia, is disrupted throughout aging and early on in neurodegenerative diseases. Our aim was to study the relationship between TREM2-dependent microglial reactivity, astroglial response and synaptic dysfunction in two longitud...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Mariana I. Muñoz-García, Yuetiva Deming, Ferran Lugo-Hernández, Sterling Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Cynthia Carlsson, Ozioma C. Okonkwo, David Pérez-Martinez, Alberto Villarejo-Galende, Kaj Blennow, Marc Suárez-Calvet, Henrik Zetterberg, Barbara B. Bendlin, Estrella Morenas-Rodríguez
Format:	Article
Language:	English
Published:	BMC 2025-10-01
Subjects:	Microglia Synaptic function Aging Neurodegeneration TREM2
Online Access:	https://doi.org/10.1186/s13024-025-00901-5