Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience

IntroductionPhosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among them, are widely used in the management of pediatric pulmonary arterial hypertension (PAH). Tadalafil is a PDE5 inhibitor with a long half life (16 h), stable pharmacokinetics and pharmacodynamics, and minimal...

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Bibliographic Details

Published in:	Frontiers in Pediatrics
Main Authors:	David Edward Youssef, Stephanie S. Handler, Susan Marjorie Richards, Catherine Anne Sheppard, Jenna Smith, Kathryn Tillman, Matthew Pietrosanu, Edward Kirkpatrick, Angela Bates
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	adverse effect echocardiography hemodynamic pulmonary vasodilator safety tolerability
Online Access:	https://www.frontiersin.org/articles/10.3389/fped.2023.1055131/full