A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation

Glioblastoma multiforme (GBM) is a highly heterogeneous disease, which is initiated and sustained by various molecular alterations in an array of signal transduction pathways. Heat-shock protein 90 (Hsp90) is a molecular chaperone and is critically implicated in folding and activation of a diverse g...

Full description

Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Hao Chen, Yuanying Gong, Yufang Ma, Reid C. Thompson, Jialiang Wang, Zhixiang Cheng, Lixia Xue
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Subjects:	glioblastoma radiation resistance Hsp90 inhibitor molecular pharmacology DNA damage response ER stress
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00974/full