A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation

Glioblastoma multiforme (GBM) is a highly heterogeneous disease, which is initiated and sustained by various molecular alterations in an array of signal transduction pathways. Heat-shock protein 90 (Hsp90) is a molecular chaperone and is critically implicated in folding and activation of a diverse g...

書誌詳細
出版年:	Frontiers in Pharmacology
主要な著者:	Hao Chen, Yuanying Gong, Yufang Ma, Reid C. Thompson, Jialiang Wang, Zhixiang Cheng, Lixia Xue
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2020-06-01
主題:	glioblastoma radiation resistance Hsp90 inhibitor molecular pharmacology DNA damage response ER stress
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fphar.2020.00974/full

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